Viropil Tablet (ART)

Description

 

Generic Name:

Viropil Tablet is a Dolutegravir + Lamivudine + Tenofovir Disoproxil Fumarate (TDF) combination used for HIV-1 treatment, PEP, and ART therapy. It works to lower HIV viral load, block viral replication, and support immune health.

 

Composition:

Each Viropil Tablet contains:

• Dolutegravir (50 mg): Dolutegravir blocks the integrase enzyme, which HIV needs to integrate its genetic material into the host’s DNA, preventing viral replication.
• Lamivudine (300 mg): Lamivudine mimics natural nucleosides and interrupts viral DNA formation, halting the replication of HIV by inhibiting reverse transcriptase.
• Tenofovir Disoproxil Fumarate (300 mg): Tenofovir competes with natural DNA building blocks, inhibiting reverse transcriptase and reducing viral DNA production, controlling HIV replication.

 

Why This Combination is Effective?

The combination of Dolutegravir (INSTI) and two NRTIs (Lamivudine + Tenofovir) offers a multi-target approach to effectively block HIV replication at different stages, making Viropil Tablet a key treatment for HIV infection and PEP.

 

Indication:

Viropil Tablet is indicated for the treatment of HIV-1 infection in adults and adolescents. It is also used as Post-Exposure Prophylaxis (PEP) to reduce the risk of HIV infection after potential exposure.

 

Storage Instructions:

• Store at 15°C to 30°C in a cool, dry place.
• Keep the medicine away from moisture and direct sunlight.
• Store in the original packaging to protect from contamination.
• Keep out of reach of children and pets.

 

Uses of the Viropil Tablet:

• Treatment of HIV-1 infection in adults and adolescents, helping reduce viral load and increase CD4 cell count to improve immune function.
• Used for Post-Exposure Prophylaxis (PEP) to prevent HIV infection after potential exposure, such as unprotected sex or needle-sharing.
• Reduces viral replication by inhibiting key enzymes, preventing HIV from spreading in the body.
• Improves long-term outcomes by lowering the risk of AIDS and opportunistic infections.
• Helps maintain viral suppression when taken as part of antiretroviral therapy (ART).

 

Viropil Tablet Price:

The Viropil Tablet price in India typically ranges around ₹2,900 for a 30-tablet pack, though prices may vary depending on the pharmacy and location. This HIV PEP (post-exposure prophylaxis) medicine is a combination of Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate (TDF), and is widely used for the treatment of HIV-1 infection.

 

Benefits of the Viropil Tablet:

• Controls HIV Viral Load: Viropil Tablet helps reduce the HIV viral load, keeping the virus suppressed and supporting effective HIV infection treatment.
• Supports Immunity: Increases CD4 cell count and lowers the risk of opportunistic infections, enhancing the immune system’s ability to fight infections.
• Once-Daily Convenience: A single-tablet, once-daily regimen that improves adherence and simplifies long-term HIV treatment.
• Helps Reduce Transmission Risk: By lowering viral load, Viropil Tablet may reduce the risk of HIV transmission when taken consistently as prescribed.

 

Common Side Effects of Viropil Tablet:

• Headache
• Nausea
• Fatigue
• Insomnia
• Diarrhea

 

Serious Side Effects of Viropil Tablet:

• Lactic acidosis (muscle pain, rapid breathing, irregular heartbeat)
• Liver toxicity (yellowing of skin/eyes, dark urine)
• Hypersensitivity reactions (rash, fever, difficulty breathing)
• Kidney dysfunction (swelling, decreased urine output)

Seek immediate medical attention if you experience any of these serious side effects.

 

How to Use the Viropil Tablet:

• Take one tablet orally once daily with or without food.
• If used for PEP, start the medicine within 72 hours of exposure and continue for 28 days.
• Swallow the tablet whole with a glass of water.
• Follow your doctor’s instructions carefully.

 

How the Viropil Tablet Works:

Viropil Tablet contains a combination of three antiretroviral drugs:

• Dolutegravir: An integrase inhibitor that prevents HIV from integrating into human DNA.
• Lamivudine: A nucleoside reverse transcriptase inhibitor (NRTI) that blocks viral replication.
• Tenofovir Disoproxil Fumarate: Another NRTI that prevents the virus from multiplying.
• Together, these drugs effectively block HIV replication and reduce the viral load.

 

What If You Forget to Take the Viropil Tablet?

• Take the missed dose as soon as you remember.
• If it is almost time for the next dose, skip the missed dose.
• Do not take a double dose to make up for the missed one.

 

Best Practices for Adherence to Viropil Tablet:

• Take at the Same Time Daily: Ensure consistency by taking Viropil Tablet at the same time each day to maintain steady drug levels.
• Do Not Miss Doses: Skipping doses can reduce effectiveness and lead to HIV resistance; follow the prescribed schedule.
• Follow Doctor’s Instructions: Take Viropil Tablet exactly as prescribed, and consult your doctor before changing the dose or stopping treatment.
• Set Reminders: Use alarms or apps to help remember your once-daily dose, ensuring adherence.

 

Quick Tips:

• Start PEP as soon as possible—ideally within 72 hours of exposure.
• Always complete the full 28-day PEP regimen to maximize effectiveness.
• Regularly monitor your liver and kidney function during treatment.
• Use barrier protection (e.g., condoms) to prevent HIV and other STIs.

Safety Advice:

 

Caution is advised when consuming alcohol with Viropil Tablet. Please consult your doctor for guidance.

 

Viropil Tablet is unsafe to use during pregnancy due to potential harm to the developing baby. It may only be prescribed in life-threatening situations where benefits outweigh the risks. Please consult your doctor.

 

There is insufficient information on the use of Viropil Tablet while breastfeeding. Please consult your doctor before use.

 

It is uncertain whether Viropil Tablet affects your ability to drive. Avoid driving if you experience drowsiness, dizziness, or reduced alertness.

 

Limited data is available on the safety of Viropil Tablet in patients with kidney disease. Dose adjustments may be necessary. Please consult your doctor.

 

Viropil Tablet should be used with caution in patients with liver disease. Dose adjustments may be required based on the severity of the condition. Please consult your doctor.

 

Manufacturer:

Viropil Tablet is manufactured by Emcure Pharmaceuticals, a well-known pharmaceutical company recognized for producing high-quality antiretroviral medicines used in HIV infection treatment.

 

FAQs:

Q: What is Viropil Tablet used for?
A: Viropil Tablet is used to treat HIV-1 infection in adults and adolescents. It is also used for Post-Exposure Prophylaxis (PEP) to prevent HIV infection after potential exposure, such as unprotected sex or needle-sharing.

 

Q: How does Viropil Tablet work?
A: Viropil Tablet contains Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate, which work together to block HIV replication, reduce viral load, and improve immune system function by increasing CD4 cell count.

 

Q: What should I do if I miss a dose of Viropil Tablet?
A: If you miss a dose of Viropil Tablet, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

 

Q: Can I take Viropil Tablet with other medications?
A: Viropil Tablet may interact with certain other medications, including those for fungal infections, tuberculosis, and seizures. Always inform your doctor about all other medications you are taking to avoid potential interactions.

 

Q: How long do I need to take Viropil Tablet for HIV treatment?
A: Viropil Tablet is a long-term treatment for HIV-1 infection. It is essential to follow the doctor’s prescription and take the medication consistently to maintain viral suppression and immune function.

 

Q: Can I stop taking Viropil Tablet once my HIV viral load is undetectable?
A: No, it is crucial to continue taking Viropil Tablet as prescribed, even if your viral load becomes undetectable. Stopping the treatment can lead to HIV resistance and potential treatment failure.

 

Q: Does Viropil Tablet prevent HIV transmission?
A: While Viropil Tablet reduces viral load and helps control HIV infection, it does not completely prevent HIV transmission. Safe sex practices and other preventive measures are still important.

 

Q: How does Viropil Tablet affect the immune system?
A: Viropil Tablet helps improve immune function by increasing CD4 cell count, which plays a key role in fighting infections. By controlling viral load, it strengthens the immune system and reduces the risk of opportunistic infections.

 

Related Lab Tests:

HIV test (before and after completing PEP)

Liver function test

Kidney function test

Viral load test (for HIV-positive individuals)

 

 

Other Resources:

WHO’s HIV/AIDS Fact Sheet