TENOF EM Tablet (PREP)

Description

Generic Name:

Tenof EM PrEP Tablet contains Tenofovir Disoproxil Fumarate (300mg) + Emtricitabine (200mg) — a fixed-dose combination of two NRTIs (Nucleoside/Nucleotide Reverse Transcriptase Inhibitors) clinically proven for HIV PrEP (Pre-Exposure Prophylaxis), helping HIV-negative individuals at high risk prevent HIV-1 infection before potential exposure.

 

Composition:

Each Tenof EM Prep Tablet contains:

• Tenofovir Disoproxil Fumarate (300mg): Tenofovir inhibits the reverse transcriptase enzyme, blocking HIV-1 DNA formation and preventing viral replication.
• Emtricitabine (200mg): Emtricitabine mimics natural nucleosides to interrupt HIV-1 DNA formation, blocking viral replication and protecting CD4 cells from HIV-1 infection.

 

Why This Combination is Effective:

The combination of two NRTIs — Tenofovir Disoproxil Fumarate + Emtricitabine — offers a dual-target approach that blocks HIV-1 reverse transcriptase at two simultaneous points, making Tenof EM Tablet the WHO-recommended gold-standard for daily oral PrEP, HIV-1 treatment, and Post-Exposure Prophylaxis (PEP).

 

Indication:

Tenof EM Prep Tablet is indicated for:

• Pre-exposure prophylaxis (PrEP) to reduce the risk of acquiring HIV-1 infection in high-risk individuals.
• Treatment of HIV-1 infection in combination with other antiretroviral agents.

 

Storage Instructions:

• Store at room temperature (15°C to 30°C).
• Keep in a cool, dry place, away from direct sunlight and moisture.
• Store in the original packaging to protect from light.
• Keep out of reach of children.

 

Uses of theTenof EM Prep Tablet:

• Prevents the transmission of HIV-1 infection (PrEP) in at-risk individuals.
• Manages HIV-1 infection in adults and adolescents.
• Reduces the viral load in the bloodstream.
• Enhances immune system function to prevent HIV-related complications.

 

Tenof EM Prep Tablet Price:

Tenof EM PrEP Tablet is available in India at approximately ₹800 per pack of 30 tablets. It offers the same Emtricitabine + Tenofovir composition as branded Truvada at a significantly lower cost, making daily oral PrEP more accessible for individuals at high risk of HIV-1 infection. Please note that prices may vary depending on pharmacy location and availability.

 

Benefits of the Tenof EM Prep Tablet:

• Controls HIV Viral Load: Suppresses HIV-1 viral load in the blood, keeping the virus under control as part of Antiretroviral Therapy (ART).
• Supports Immunity: Increases CD4 cell count, lowering the risk of opportunistic infections and AIDS complications.
• Once-Daily Convenience: A single once-daily tablet improves long-term adherence to HIV treatment, PrEP, and PEP regimens.
• Effective HIV-1 Prevention: Clinically proven PrEP and PEP protection against HIV-1 infection for high-risk individuals.
• Reduces Transmission Risk: Lowers HIV viral load, reducing transmission risk in serodiscordant couples.

 

Common Side Effects of Tenof EM Prep Tablet:

• Nausea
• Headache
• Dizziness
• Fatigue
• Diarrhea

 

Serious Side Effects of Tenof EM Prep Tablet:

• Lactic acidosis (symptoms: nausea, weakness, difficulty breathing)
• Kidney problems (reduced urination, swelling)
• Bone density loss (increased risk of fractures)
• Liver toxicity (yellowing of the skin or eyes, dark urine)
• Severe allergic reactions (rash, fever, swelling)

Seek immediate medical attention if you experience any severe side effects.

 

How to Use the Tenof EM Prep Tablet:

• Take Tenof EM Prep Tablet exactly as prescribed by your healthcare provider.
• Swallow the tablet whole with water.
• Take it once daily, preferably at the same time each day.
• For PrEP, ensure regular HIV testing before and during use.
• Do not stop the medication without consulting your doctor.

 

How the Tenof EM Prep Tablet Works:

• Blocks Reverse Transcriptase: Inhibits the key HIV-1 enzyme needed for viral replication.
• Terminates HIV-1 DNA Chain: Inserts into HIV-1 DNA, causing premature termination and stopping replication.
• Pre-loads CD4 Cells: Builds protective drug levels inside CD4 cells before HIV-1 exposure.
• Reduces Viral Load: Continuously suppresses HIV-1 viral load in the bloodstream.
• Supports Immune Recovery: Increases CD4 cell count, reducing risk of opportunistic infections.

 

What If You Forget to Take the Tenof EM Prep Tablet?

• Take the missed dose as soon as you remember.
• If it is close to your next scheduled dose, skip the missed dose.
• Do not double the dose to make up for a missed one.
• Consistent use is essential for effective prevention and treatment.

 

Best Practices for Adherence to Tenof EM Prep Tablet:

• Take Once Daily at the Same Time: Set a daily reminder to maintain consistent protective PrEP drug levels for maximum HIV-1 prevention.
• Never Skip a Dose: Missing doses reduces protective drug levels, increasing the risk of HIV-1 infection.
• Regular HIV & Kidney Testing: Get tested for HIV-1 every 3 months and monitor kidney function regularly for safe long-term PrEP use.
• Consult Your Doctor Before Stopping: Never discontinue Tenof EM PrEP without medical advice to avoid reduced HIV-1 protection.

 

Quick Tips:

• For PrEP, ensure you are HIV-negative before starting Tenof EM Prep Tablet.
• Always follow your doctor’s instructions for proper usage.
• Regular blood tests are necessary to monitor kidney and liver function.
• Use condoms consistently for additional protection against sexually transmitted infections (STIs).
• If you experience severe side effects, consult your healthcare provider immediately.

 

Safety Advice:

 

Caution is advised when consuming alcohol with TENOF EM Tablet. Please consult your doctor for guidance.

 

TENOF EM Tablet is unsafe to use during pregnancy due to potential harm to the developing baby. It may only be prescribed in life-threatening situations where benefits outweigh the risks. Please consult your doctor.

 

There is insufficient information on the use of TENOF EM Tablet while breastfeeding. Please consult your doctor before use.

 

It is uncertain whether TENOF EM Tablet affects your ability to drive. Avoid driving if you experience drowsiness, dizziness, or reduced alertness.

 

Limited data is available on the safety of TENOF EM Tablet in patients with kidney disease. Dose adjustments may be necessary. Please consult your doctor.

 

TENOF EM Tablet should be used with caution in patients with liver disease. Dose adjustments may be required based on the severity of the condition. Please consult your doctor.

 

Manufacturer:

Tenof EM PrEP Tablet is manufactured by Hetero, a well-known pharmaceutical company recognized for producing high-quality antiretroviral medicines used in HIV-1 treatment. Hetero has a strong presence in the healthcare sector and is known for offering reliable therapies that support effective viral suppression and long-term HIV management.

 

FAQs:

Q: What is Tenof EM PrEP Tablet used for?

A: Tenof EM PrEP Tablet is used for Pre-Exposure Prophylaxis (PrEP) to prevent HIV-1 infection in high-risk HIV-negative individuals. It is also used for HIV-1 treatment as part of Antiretroviral Therapy (ART) and Post-Exposure Prophylaxis (PEP) after potential HIV-1 exposure.

 

Q: How effective is Tenof EM PrEP in preventing HIV-1 infection?

A: When taken consistently as daily oral PrEP, Tenof EM Tablet reduces the risk of HIV-1 infection by up to 99% in high-risk individuals. Effectiveness depends on strict daily adherence — missing doses reduces protective drug levels in CD4 cells and tissues.

 

Q: How long does Tenof EM PrEP take to become effective?

A: Tenof EM PrEP reaches maximum protective drug levels in:

• Rectal tissue — within 7 days of consistent daily dosing
• Vaginal/cervical tissue — within 20 days of consistent daily dosing
• Blood plasma — within 7 days of consistent daily dosing

 

Q: What is the recommended Tenof EM PrEP dosage?

A: The recommended Tenof EM PrEP dosage is one tablet once daily, taken with or without food at the same time every day. For event-driven PrEP (2-1-1), consult your doctor for a tailored dosing schedule based on your HIV-1 exposure risk pattern.

 

Q: Does Tenof EM PrEP affect kidney function?

A: Tenofovir Disoproxil Fumarate in Tenof EM PrEP can affect kidney function in some individuals with long-term use. Regular kidney function monitoring every 3–6 months is recommended for all individuals on daily oral PrEP. Consult your doctor immediately if you experience reduced urination or swelling during PrEP use.

 

Q: Can Tenof EM PrEP Tablet be taken during pregnancy?

A: Tenof EM PrEP Tablet may be prescribed during pregnancy if the benefit outweighs the risk, particularly for HIV-negative pregnant women at high risk of HIV-1 infection. WHO supports PrEP use during pregnancy for serodiscordant couples. Always consult your doctor before starting or continuing Tenof EM PrEP during pregnancy.

 

Q: Does Tenof EM PrEP interact with other medicines?

A: Tenof EM PrEP may interact with the following medicines:

• NSAIDs (ibuprofen, naproxen) — may increase kidney toxicity risk
• Hepatitis C medicines (sofosbuvir) — may increase Tenofovir levels
• Aminoglycosides (antibiotics) — may increase kidney damage risk
• Antacids containing aluminium or magnesium — may reduce drug absorption

 

Q: Q: Does Tenof EM PrEP protect against other STIs?

A: No. Tenof EM PrEP Tablet only protects against HIV-1 infection and does not provide protection against other sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, or herpes. Always use condoms alongside Tenof EM PrEP for comprehensive sexual health protection.

 

Related Lab Tests:

• HIV test (before and during PrEP use)
• Kidney function tests (creatinine clearance)
• Liver function tests
• Bone density monitoring (for long-term use)

 

Other Resources:

WHO Guidelines on PrEP Use